Research
RegeneVive takes pride in aligning our products and services with the best and the brightest in regenerative medicine and scientific research. We invite you to refer to the following publications to enhance your understanding of this field.
Scientific Publications
Gupta, A., Ibim, S. E., Levy, H., Sze Tu, R., & El-Amin, S. F. III. (2025). A Novel Umbilical Cord Derived Wharton’s Jelly Formulation for Regenerative Medicine Applications. BioIntegrate LLC, New York, NY, USA.
Gupta, A. (2022). Allogenic Amniotic Tissue for Treatment of Knee and Hip Osteoarthritis. Pharmaceuticals, 15(4), 404. https://doi.org/10.3390/ph15040404
Gupta, A., Aratikatla, A., & Martin, S. M. (2023). Allogenic Platelet-Rich Plasma for the Treatment of Adhesive Capsulitis. Cureus, 15(10), e47491. https://doi.org/10.7759/cureus.47491
Gupta, A., & Aratikatla, A. (2023). Allogenic Umbilical Cord Tissue as a Scaffold for Ankle Osteoarthritis. Cureus, 15(10), e46572. https://doi.org/10.7759/cureus.46572
Gupta, A., & Maffulli, N. (2022). Allogenic Umbilical Cord Tissue for Treatment of Knee Osteoarthritis. Sports Medicine and Arthroscopy Review, 30(3), 162-165. https://doi.org/10.1097/JSA.0000000000000350
Gupta, A., Rastmanesh, R., Bowirrat, A., Gilley, E., & Blum, K. (2023). Anti(angiogenic) food components: can be a major source of bias in the investigation of angiogenesis inhibitors. Annals of Translational Medicine, 11(12), 419. https://dx.doi.org/10.21037/atm-23-1517
Maffulli, N., Rodriguez, H. C., Stone, I. W., Nam, A., Song, A., Gupta, M., Alvarado, R., Ramon, D., & Gupta, A. (2020). Artificial intelligence and machine learning in orthopedic surgery: a systematic review protocol. Journal of Orthopaedic Surgery and Research, 15, 478. https://doi.org/10.1186/s13018-020-02002-z
Gupta, A., & Jain, V. (2024). Autologous Conditioned Plasma (ACP) and Osteoarthritis of the Knee: A Review of Current Clinical Evidence. Cureus, 16(1), e52693. https://doi.org/10.7759/cureus.52693
Jeyaraman, N., Jeyaraman, M., Ramasubramanian, S., Yadav, S., Balaji, S., Patro, B. P., & Gupta, A. (2024). Autologous Conditioned Serum in Knee Osteoarthritis: A Systematic Review of Current Clinical Evidence. Cureus, 16(9), e68963. https://doi.org/10.7759/cureus.68963
Gupta, A., & Potty, A. G. (2024). Autologous Peripheral Blood-Derived Orthobiologics for the Management of Hip Osteoarthritis: A Systematic Review of Current Clinical Evidence. Cureus, 16(10), e70985. https://doi.org/10.7759/cureus.70985
Gupta, A., & Potty, A. G. (2024). Autologous Peripheral Blood-Derived Orthobiologics for the Management of Hip Osteoarthritis: A Systematic Review of Current Clinical Evidence. Cureus, 16(10), e70985. https://doi.org/10.7759/cureus.70985
Ram, P. R., Jeyaraman, M., Jeyaraman, N., Nallakumarasamy, A., Khanna, M., Gupta, A., & Yadav, S. (2023). Beyond the Pain: A Systematic Narrative Review of the Latest Advancements in Fibromyalgia Treatment. Cureus, 15(10), e48032. https://doi.org/10.7759/cureus.48032
Gupta, A., Liberati, T. A., Verhulst, S. J., Main, B. J., Roberts, M. H., Potty, A. G. R., Pylawka, T. K., & El-Amin, S. F. III. (2015). Biocompatibility of single-walled carbon nanotube composites for bone regeneration. Bone & Joint Research, 4(5), 70-77. https://doi.org/10.1302/2046-3758.45.2000382
Bowen, C. M., Ditmars, F. S., Gupta, A., Reems, J.-A., & Fagg, W. S. (2022). Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities. Biomedicines, 10(11), 2960. https://doi.org/10.3390/biomedicines10112960
Gupta, A., Cady, C., Fauser, A.-M., Rodriguez, H. C., Mistovich, R. J., Potty, A. G. R., & Maffulli, N. (2020). Cell-free Stem Cell-Derived Extract Formulation for Regenerative Medicine Applications. International Journal of Molecular Sciences, 21(24), 9364. https://doi.org/10.3390/ijms21249364
Gupta, A. (2022). Cell-free Stem Cell-Derived Extract Formulation for Treatment of Knee Osteoarthritis. Journal of Orthopedics & Orthopedic Surgery, 3(1), 23-25.
Gupta, A. (2022). Cell-free Stem Cell-Derived Extract Formulation for Treatment of Knee Osteoarthritis. Journal of Orthopedics & Orthopedic Surgery, 3(1), 23-25.
Kashte, S., Gulbake, A., El-Amin III, S. F., & Gupta, A. (2021). COVID-19 vaccines: rapid development, implications, challenges and future prospects. Human Cell, 34, 711-733. https://doi.org/10.1007/s13577-021-00512-4
Das, T., Mathur, M., Gupta, A. K., Janssen, G. M. C., & Banerjee, A. K. (1998). RNA polymerase of vesicular stomatitis virus specifically associates with translation elongation factor-1 αβγ for its activity. Proceedings of the National Academy of Sciences, 95(4), 1449-1454. https://doi.org/10.1073/pnas.95.4.1449
Gupta, A. (2024). Exosomes for the Management of Low Back Pain: A Review of Current Clinical Evidence. Cureus, 16(4), e57539. https://doi.org/10.7759/cureus.57539
Aratikatla, A., Arcot, S., Gupta, M., & Gupta, A. (2024). Exosomes for the Management of Rotator Cuff Injuries.
Karki, R., Gupta, A., Maffulli, N., Albers, C., Roberts, M. H., & El-Amin, S. F. (2023). Human anterior cruciate ligament-derived mesenchymal stem cells for regenerative medicine applications. IP International Journal of Orthopaedic Rheumatology, 9(1), 35-45. https://doi.org/10.18231/j.ijor.2023.006
Gupta, A., & Aratikatla, A. (2024). Hyperacute Serum and Knee Osteoarthritis. Cureus, 16(1), e53118. https://doi.org/10.7759/cureus.53118
Gupta, A., Shivaji, K., Kadam, S., Gupta, M., Rodriguez, H. C., Potty, A. G., El-Amin, S. F., & Maffulli, N. (2021). Immunomodulatory extracellular vesicles: an alternative to cell therapy for COVID-19. Expert Opinion on Biological Therapy, 21(12), 1551-1560. https://doi.org/10.1080/14712598.2021.1921141
Gupta, A., Woods, M. D., Illingworth, K. D., Niemeier, R., Schafer, I., Cady, C., Filip, P., & El-Amin III, S. F. (2013). Single walled carbon nanotube composites for bone tissue engineering. Journal of Orthopaedic Research, 31(9), 1374-1381. https://doi.org/10.1002/jor.22379
Gupta, A., Viswanath, A., & Kumar, G. H. (2024). Leukocyte-Poor Platelet-Rich Plasma for the Management of Knee Osteoarthritis: A Retrospective Study With 12 Months of Follow-Up. Cureus, 16(9), e69662. https://doi.org/10.7759/cureus.69662
Gupta, A., Kashte, S., Gupta, M., Rodriguez, H. C., Gautam, S. S., & Kadam, S. (2020). Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective. Human Cell, 33(4), 907-918. https://doi.org/10.1007/s13577-020-00407-w
Nallakumarasamy, A., Jeyaraman, M., Maffulli, N., Jeyaraman, N., Suresh, V., Ravichandran, S., Gupta, M., Potty, A. G., El-Amin III, S. F., Khanna, M., & Gupta, A. (2022). Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Wound Healing. Life, 12(11), 1733. https://doi.org/10.3390/life12111733
Vallejo, R., Kelley, C. A., Gupta, A., Smith, W. J., Vallejo, A., & Cedeño, D. L. (2020). Modulation of neuroglial interactions using differential target multiplexed spinal cord stimulation in an animal model of neuropathic pain. Molecular Pain, 16, 1-13. https://doi.org/10.1177/1744806920918057
Jeyaraman, M., Selvaraj, P., Halesh, M. B., Jeyaraman, N., Nallakumarasamy, A., Gupta, M., Maffulli, N., & Gupta, A. (2022). Monkeypox: An Emerging Global Public Health Emergency. Life, 12(10), 1590. https://doi.org/10.3390/life12101590
Chu, M., Wang, H., Bian, L., Huang, J., Wu, D., Zhang, R., Fei, F., Chen, Y., & Xia, J. (2022). Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell Derived Exosomes for COVID-19 Pneumonia. Stem Cell Reviews and Reports, 18(6), 2152-2163. https://doi.org/10.1007/s12015-022-108-w
Cady, C., Nair, K., Rodriguez, H. C., Rust, B., Ghandour, S., Potty, A., & Gupta, A. (2024). Optimization of Polycaprolactone and Type I Collagen Scaffold for Tendon Tissue Regeneration. Cureus, 16(3), e56930. https://doi.org/10.7759/cureus.56930
Gupta, A., & Maffulli, N. (2024). Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence. Pain and Therapy. https://doi.org/10.1007/s40122-024-00661-y
Al-Khawaga, S., & Abdelalim, E. M. (2020). Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients. Stem Cell Research & Therapy, 11, 437. https://doi.org/10.1186/s13287-020-01963-6
Akbari, A., & Rezaie, J. (2020). Potential therapeutic application of mesenchymal stem cell-derived exosomes in SARS-CoV-2 pneumonia. Stem Cell Research & Therapy, 11, 356. https://doi.org/10.1186/s13287-020-01866-6
Navani, A., Manchikanti, L., Albers, S. L., Latchaw, R. E., Sanapati, J., Kaye, A. D., Atluri, S., Jordan, S., Gupta, A., Cedeno, D., Vallejo, A., Fellows, B., Knezevic, N. N., Pappolla, M., Diwan, S., Trescot, A. M., Soin, A., Kaye, A. M., Aydin, S. M., Calodney, A. K., Candido, K. D., Bakshi, S., Benyamin, R. M., Vallejo, R., Watanabe, A., Beall, D., Stitik, T. P., Foye, P. M., Helander, E. M., & Hirsch, J. A. (2019). Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician, 22(1S), 1-1.
Gupta, A., Kukkar, N., Sharif, K., Main, B. J., Albers, C. E., & El-Amin III, S. F. (2015). Bone graft substitutes for spine fusion: A brief review. World Journal of Orthopedics, 6(6), 449-456. https://doi.org/10.5312/wjo.v6.i6.449
Jeyaraman, M., Nagarajan, S., Maffulli, N., Packkyarathinam, R. P., Jeyaraman, N., Arulkumar, N., Khanna, M., Yadav, S., & Gupta, A. (2023). Stem Cell Therapy in Critical Limb Ischemia. Cureus, 15(7), e41772. https://doi.org/10.7759/cureus.41772
Gupta, A. (2023). StemOne™/Stempeucel®: CDSCO Approved, Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogenic Mesenchymal Stem Cells for Knee Osteoarthritis. Biomedicines, 11, 2894. https://doi.org/10.3390/biomedicines11112894
Jeyaraman, M., Maffulli, N., & Gupta, A. (2023). Stromal Vascular Fraction in Osteoarthritis of the Knee. Biomedicines, 11, 1460. https://doi.org/10.3390/biomedicines11051460
Rodriguez, H. C., Gupta, M., Cavazos-Escobar, E., El-Amin, S. F. III, & Gupta, A. (2021). Umbilical cord: an allogenic tissue for potential treatment of COVID-19. Human Cell, 34, 1-13. https://doi.org/10.1007/s13577-020-00444-5
Main, B.J., Maffulli, N., Valk, J.A., Rodriguez, H.C., Gupta, M., El-Amin, S.F., III, & Gupta, A. (2021). Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review. Pharmaceuticals, 14(11), 1090. https://doi.org/10.3390/ph14111090
Gupta, A., Maffulli, N., Rodriguez, H. C., Lee, C. E., Levy, H. J., & El-Amin, S. F. III. (2021). Umbilical cord-derived Wharton’s jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial. Journal of Orthopaedic Surgery and Research, 16, 143. https://doi.org/10.1186/s13018-021-02300-0
Aratikatla, A., Maffulli, N., Gupta, M., Potti, I.A., Potty, A.G., & Gupta, A. (2024). Wharton’s jelly and osteoarthritis of the knee. British Medical Bulletin, 149(1), 13-31. https://doi.org/10.1093/bmb/ldad030
Gupta, A. (2025). Wharton’s Jelly: A Promising Source for Regenerative Medicine. Journal of Orthopaedic Surgery and Research. (In Press).
Gupta, Ashim et al. “Umbilical cord-derived Wharton’s jelly for regenerative medicine applications.” Journal of Orthopaedic Surgery and Research, vol. 15, no. 1, 2020, doi:10.1186/s13018-020-1553-7.
Aratikatla, A., Maffulli, N., Gupta, M., Potti, I. A., Potty, A. G., & Gupta, A. (2024). Wharton’s Jelly and Osteoarthritis of the Knee. British Medical Bulletin, 149(1), 13-31. https://doi.org/10.1093/bmb/ldad030
Scientific Journals
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Experience and Education
Professional Experience
- Founder and CEO: Future Biologics and Regenerative Orthopaedics
- Professor and Chief Science Officer: South Texas Orthopaedic Research Institute
- Associate Director: Millennium Pain Center
- Assistant Professor and Director of Laboratory for Regenerative Medicine and Applied Sciences: Southern Illinois University School of Medicine
Education
- MS and PhD: Southern Illinois University School of Medicine
- MBA: Southern Illinois University Edwardsville