Arthrosamid for Knee Pain – And Why Stem Cell Therapy May Be a Better Option
If you’re dealing with ongoing knee pain, swelling, or stiffness due to osteoarthritis, you’ve probably searched for long-term relief that doesn’t involve surgery. One name that may have come up recently is Arthrosamid—a hydrogel injection gaining traction overseas for knee pain treatment.
But how does Arthrosamid work? Is it available in the U.S.? And how does it compare to more advanced, regenerative approaches like stem cell therapy?
Let’s take a closer look at Arthrosamid reviews, how it works, and why stem cell therapy may be a preferred, healing-based alternative.
What Is Arthrosamid?
Arthrosamid is a non-biodegradable hydrogel designed to be injected directly into the knee joint. This arthrosamid injection is intended to cushion and lubricate the joint for people with knee osteoarthritis. The gel, made from 2.5% cross-linked polyacrylamide and 97.5% water, integrates into the soft tissue of the knee lining (synovium) to reduce pain and improve mobility.
Unlike cortisone or hyaluronic acid injections, Arthrosamid isn’t absorbed by the body over time. It’s meant to stay in place as a long-term buffer between bones. Many patients exploring arthrosamid knee injection options are hoping for extended relief without repeated procedures.
How Does Arthrosamid Work?
The mechanism behind Arthrosamid treatment is purely mechanical. It doesn’t regenerate cartilage, reduce inflammation at the cellular level, or trigger healing in the joint. Instead, it creates a thick gel pad inside the joint that may relieve pressure and make movement more comfortable.
When Will Arthrosamid Be Available in the USA?
A common question patients ask is: When will Arthrosamid be available in USA?
As of now, Arthrosamid has not been approved by the FDA. It’s undergoing clinical trials, and it could take years before becoming available in the U.S.—if it’s approved at all. In the meantime, patients looking for non-surgical options are left searching.
Arthrosamid vs Hyaluronic Acid: What’s the Difference?
Both Arthrosamid and hyaluronic acid (HA) injections are used for knee pain. But their differences are important:
HA is a natural compound already found in your joints, but it’s quickly absorbed, requiring repeat injections every 6–12 months.
Arthrosamid is synthetic and meant to stay in place much longer, but it doesn’t improve joint health or structure.
And while HA is widely available in the U.S., Arthrosamid remains out of reach for now.
Why Stem Cell Therapy May Be a Better Solution
While Arthrosamid focuses on mechanical cushioning, stem cell therapy goes deeper, working with your body to promote real healing from the inside out.
Stem cells are natural repair cells that can:
Regrow cartilage damaged by osteoarthritis
Reduce inflammation in the joint
Improve joint lubrication and function
Support long-term recovery without synthetic implants
And the best part? Stem cell therapy is available right now in the U.S., including at RegeneVive Health and Wellness.
How Stem Cell Therapy Works for Knee Pain
Stem cell therapy involves collecting and injecting healing cells into your damaged joint. At RegeneVive, here’s how we do it:
Step 1: Personalized Assessment
We use imaging and evaluation to understand the extent of your joint damage and create a customized treatment plan.
Step 2: Stem Cell Collection
Stem cells are collected using a safe, minimally invasive method.
Step 3: Precision Injection
Stem cells are processed and injected into the knee under image guidance to ensure accuracy and effectiveness.
Once injected, they go to work:
- Repairing cartilage
- Reducing inflammation
- Regenerating tissue
- Improving overall joint health
Stem cell therapy offers a powerful, non-surgical option to help your knees heal from within. By targeting inflammation, regenerating tissue, and supporting cartilage repair, it works to relieve pain and improve mobility, so you can get back to living without limits.
Arthrosamid vs Stem Cell Therapy: A Side-by-Side Comparison
| Feature | Arthrosamid | Stem Cell Therapy |
| FDA Approved in the USA | ❌ Not yet | ✅ Yes (under specific protocols) |
| Repairs Cartilage | ❌ No | ✅ Yes |
| Reduces Inflammation | ❌ No | ✅ Yes |
| Treats the Root Cause | ❌ No (only cushions) | ✅ Yes |
| Regenerative Effect | ❌ No | ✅ Yes |
| Synthetic Material | ✅ Yes | ❌ No |
| Available Now in the USA | ❌ No | ✅ Yes |
What the Research Says About Stem Cell Therapy
A 2025 study published in Stem Cell Research & Therapy reviewed eight high-quality clinical trials involving 502 patients with knee osteoarthritis who had not undergone surgery. The researchers wanted to find out how effective and safe it is to use stem cell injections—without any other treatments—for relieving joint pain and improving mobility.
Here’s what they found:
Patients who received stem cell injections had significantly less pain and better joint function at both 6 and 12 months after treatment.
The results were even better in people who received higher doses of stem cells
Most importantly, there were no serious safety issues. Side effects like swelling or discomfort were mild and temporary, similar to what you'd expect from any injection.
This study shows that stem cell therapy not only reduces pain but also helps improve how your knee works, all without surgery or synthetic implants. And because the treatment uses your body’s regenerative power, it comes with fewer risks than invasive procedures or long-term medication.
A 2023 review in Cellular and Molecular Immunology examined clinical studies involving mesenchymal stem cell therapy for knee osteoarthritis. The review looked at 15 randomized clinical trials involving over 600 patients. Most of these studies found that MSC therapy significantly reduced knee pain and improved joint function. 18 out of 21 studies also showed evidence of cartilage preservation or regeneration, a key factor in slowing down the progression of osteoarthritis.
However, not every patient experienced the same level of improvement. The review pointed out that results varied depending on factors like the source of the stem cells, how they were processed, the dose used, and individual patient characteristics. That’s why it’s important to receive your stem cell therapy from experienced professionals who understand how to customize treatment for your specific needs.
Why RegeneVive Health and Wellness?
At RegeneVive, we focus on what works for healing your body naturally. Our regenerative therapies are:
- Clinically guided and evidence-based
- Tailored to your unique needs
- Performed by experienced professionals
- Designed to reduce pain while promoting true recovery
We believe that real healing doesn’t come from synthetic implants, but from unlocking your body’s natural ability to repair and regenerate.
Take the Next Step Toward Knee Healing
If you’re waiting for Arthrosamid in the USA, you may be waiting for a while. But if you’re ready to repair your joint now, stem cell therapy offers a powerful alternative—without surgery or synthetic implants.
Contact RegeneVive Health and Wellness today to schedule your consultation and learn how stem cell therapy can help you regain comfort, strength, and mobility naturally.